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Pharmacodynamics of recombinant staphylokinase(rSaK) as thrombolytic therapy in acute thromboembolic stroke in piglets
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1671-0282.2002.03.004
- Key Word:
- 脑梗死;溶栓疗法;基因重组;葡萄球菌激酶
Abstract： 目的研究重组葡激酶(rSaK)治疗急性脑梗塞的药效学.方法幼猪72头,分7个静脉组,3个动脉组及2个对照组.幼猪脑梗塞4h后分别经腹壁静脉和颈部动脉导管应用不同剂量的rSaK,用药结束后0.5、1.0、1.5h测颈内动脉血流量并行脑血管造影.24h后取脑作病理检查.结果静脉组0.8万U/kg或以上剂量的血管再通率均大于对照组(P＜0.05);相同剂量动脉组与静脉组血管再通率几乎相同.血管完全再通、部分再通及不通的脑梗塞发生率分别为6.38%、33.3%、100%(P＜0.05),未见脑出血并发症.结论静脉用rSaK治疗急性脑梗塞的最低有效剂量为0.8万U/kg,用药途径对疗效无明显影响.
- [1]C H, LACK.Staphylokinase; an activator of plasma protease.[J].1948,161.
- [2]H. Roger LIJNEN,Berthe VAN HOEF,Désiré COLLEN.Interaction of staphylokinase with different molecular forms of plasminogen[J].1993,211(1-2).
- [3]Vanderschueren S.,Barrios L.,Kerdsinchai P.,etc.A Randomized Trial of Recombinant Staphylokinase Versus Alteplase for Coronary Artery Patency in Acute Myocardial Infarction[J].1995.
- [4]O, Matsuo,K, Okada,H, Fukao,etc.Thrombolytic properties of staphylokinase.[J].1990,76.