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The effect of rhubarb on oxygen radicals leakage from the mitochondria of rat liver in sepsis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1671-0282.2002.02.008
- Key Word:
- 烧伤;内毒素;线粒体;肝脏;氧自由基
Abstract： 目的研究大黄对烫伤加内毒素"二次打击"后大鼠肝细胞线粒体内单价氧自由基泄漏的影响.方法采用大鼠背部烫伤模型,烫伤12h后给予内毒素(20mg/kg)"二次打击",监测肝细胞线粒体内细胞色素氧化酶的活力,同时测定肝细胞线粒体内过氧化物歧化酶(SOD)活力.结果脓毒症大鼠肝细胞线粒体内细胞色素氧化酶的活力随时间而降低,大黄能显著提高细胞色素氧化酶的活力.脓毒症大鼠肝细胞线粒体内SOD大量消耗,而大黄能显著降低肝细胞线粒体内SOD的消耗.结论大黄能显著提高脓毒症大鼠肝细胞线粒体内SOD和细胞色素氧化酶的活力,降低肝细胞线粒体内单价泄漏.
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