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Effects of propofol on the level of nitric oxide and related factors in patients with acute cerebral injury
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1671-0282.2002.02.004
- Key Word:
- 一氧化氮;一氧化氮合成酶;氧自由基;脑损伤;二异丙酚
Abstract： 目的观察异丙酚(PRO)对急性颅脑损伤(ACI)患者围术期血内一氧化氮(NO)产量、一氧化氮合成酶(NOS)、红细胞超氧化物歧化酶(SOD)活性、氧自由基(OFR)含量的影响.方法 40例ACI患者随机分为PRO组和γ-OH组.观察自麻醉诱导前至开颅手术去骨瓣后1,3,6,12,24h(T0～T5)诸指标水平变化.并以40例健康者作术前对照.结果与正常对照组相比,两组术前NOS、OFR均显著增高(P＜0.05,P＜0.01),SOD显著降低(P＜0.01).与γ-OH组相比,PRO组NO、NOS自始至终呈降低趋势,NOS于T1、SOD于T2、NO及OFR于T3时达到正常水平(与T0相比均P＜0.01).结论临床麻醉剂量的PRO具有非选择性NOS抑制剂、OFR清除剂特性,对ACI患者有多位点的脑保护作用.
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