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The protective effects of rhubarb on mitochondria function of intestinal mucosa in burned rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2002.01.005
- Key Word:
- 大黄;线粒体;烫伤;小肠粘膜
Abstract： 目的研究大黄对烫伤后大鼠肠粘膜上皮细胞线粒体呼吸链的影响.方法采用大鼠背部烫伤模型,分离小肠粘膜上皮细胞内线粒体,监测细胞色素aa3、b、c、c1和能荷的水平.结果烫伤后6h肠粘膜上皮细胞线粒体细胞色素aa3、b、和c1出现明显丢失;而细胞色素c和能荷在烫伤后半小时即有明显下降,于伤后6h最为严重.大黄治疗后细胞色素aa3、b、c、c1和能荷显著提高(P＜0.05vs烫伤组).结论烫伤能导致肠粘膜上皮细胞线粒体呼吸链明显受损、能量合成障碍,而大黄能明显改善线粒体的呼吸功能.
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