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Clinical study of reperfusion injuries in patients during cardiopulmonary resuscitation
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1671-0282.2001.06.004
- Key Word:
- 心搏骤停;心肺复苏;缺血-再灌流损伤;丙二醛;超氧化物歧化酶
Abstract： 目的探讨心肺复苏期间患者缺血-再灌流损伤的机制.方法 20例心搏骤停行心肺复苏术患者,根据复苏后有无自主循环分为缺血组(8例)和再灌流组(12例),并于复苏前,复苏后即刻,15min、30min时分别测定其血中丙二醛(MDA)和超氧化物歧化酶(SOD)的浓度,比较两组患者血中上述指标的动态变化,并设正常对照组.结果再灌流组MDA浓度较心搏骤停前明显增高,尤以30min时增高显著,且明显高于缺血组,SOD浓度较心搏骤停前明显下降,尤以复苏后即刻下降显著,且明显低于缺血组.缺血组实施心肺复苏术前后MDA、SOD浓度无明显变化.结论 MDA和SOD在缺血-再灌流损伤中起着重要作用,动态监测血中MDA、SOD浓度对评估心肺复苏期间患者的再灌流损伤程度有参考价值.
- [1]王万铁,徐正,王卫,等.川芎嗪注射液抗脑缺血-再灌流损伤作用机制的实验研究[J].2001,(3).
- [2]E, Róth,J, Lantos,G, Temes,etc.Cardioprotection during heart ischemia-reperfusion.[J].1997,36(1-4).
- [3]Kailash Prasad,Jawahar Kalra,Baikunth Bharadwaj,etc.Increased oxygen free radical activity in patients on cardiopulmonary bypass undergoing aortocoronary bypass surgery[J].1992,123(1).
- [4]K, Prasad,W P, Chan,B, Bharadwaj.Superoxide dismutase and catalase in protection of cardiopulmonary bypass-induced cardiac dysfunction and cellular injury.[J].1996,12(10).