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Effects of Ramipril on plasma concentrat ion of IL-1β in acute lung injury
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1671-0282.2001.05.004
- Key Word:
- IL-1β;雷米普利;急性肺损伤
Abstract： 目的探讨内毒素(LPS)诱导急性肺损伤(ALI)时IL-1 β含量变化及雷米普利对IL-1β及ALI的影响.方法给SD大鼠腹腔注射LPS(6mg/kg),制成ALI模型,动物随机分成正常对照组(NS组)、内毒素损伤组(LPS组)和雷米普利组 (RAM组),采用放免分析法检测LPS攻击后0、1、3、5h大鼠血浆IL-1β含量,光镜观察大鼠肺病理形态学变化.结果 LPS组大鼠1h血浆IL -1β含量明显高于正常对照组(P＜0.01),5h肺病理组织学改变严重.RAM组1 hIL-1β含量明显低于LPS组(P＜0.01),5h肺损伤也较轻.结论 IL-1β在LPS诱导的ALI中起重要作用,雷米普利有拮抗IL-1 β及明显减轻LPS导致的ALI的作用.
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