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The mRNA of cytokines expression in the lungs of rats with acute severe cholangitis-induc ed ARDS
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1671-0282.2001.05.003
- Key Word:
- 急性粳阻性化脓性胆管炎;急性呼吸窘迫综合征;细胞因子
Abstract： 目的观察急性梗阻性化脓性胆管炎大鼠ARDS时肺组织内TNF -α、IL-1β的mRNA变化.方法通过胆总管远端结扎,近端注入菌液并封闭的方法,造成大鼠AOSC模型,观察肺功能改变.应用原位杂交的方法检测肺组织内TNF-α、IL-1β的mRNA表达.结果模型组PaO2/FiO2下降;肺系数升高,肺含水量增加;IL- 1β、TNF-α的mRNA杂交信号主要位于巨噬细胞内.模型组明显高于假手术组 .结论 AOSC时肺内》巨噬细胞释放大量的炎性细胞因子, 发挥局部效应,导致ARDS.
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