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The relationship between the changes in plasma endotoxin,tumor necrosis factor levels and multiple organ dysfunction syndrome in patients with moderate severe acute orgaophosphorus pesticide poisoning

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF EMERGENCY MEDICINE
Issue:
4
DOI:
10.3760/cma.j.issn.1674-5760.2001.04.001
Key Word:
有机磷中毒;内毒素;肿瘤坏死因子;多器官功能障碍综合征

Abstract: 目的探讨血浆内毒素(LPS)及肿瘤坏死因子(TNF)在中重度急性有机磷中毒(AOPP)后多器官功能障碍综合征(MODS)发生发展中的作用、机制及其临床意义.方法应用动态浊度法及放射免疫法动态监测46例中重度AOPP患者血浆LPS和TNF水平的变化,比较MODS组、非MODS组及正常对照组LPS及TNF的变化.结果 46例患者血浆LPS及TNF水平均明显升高,较正常对照组差异非常显著(P均<0.01),且血浆高水平持续较长时间,MODS组升高的峰值较非MODS组更显著(P<0.05和P<0.01).结论中重度AOPP的早期即可有内毒素血症的发生,内毒素可能是导致炎性介质产生和释放的重要机制,是有机磷中毒机制的重要组成之一.血浆LPS与TNF的高水平可能参与了中重度AOPP后MODS的发病过程.

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