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Studies of Rhubarb against gastrointestinal complications in critically ill patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1671-0282.2001.03.006
- Key Word:
- 大黄;脓毒症;应激性胃肠粘膜病变;肠麻痹;血流动力学
Abstract： 目的研究大黄对危重病患者胃肠道并发症的治疗作用.方法采用SWAN-GANZ导管监测血流动力学和全身氧输送和氧消耗.应用胃肠粘膜内pH值检测胃肠粘膜的血液灌流和氧合情况.观察大黄对危重病患者应激性胃肠粘膜病变及中毒性肠麻痹的疗效.结果:大黄对危重症患者应激性胃肠粘膜病变伴出血的止血有效率达73%,与洛赛克对照治疗组无差异;大黄对中毒性肠麻痹的有效率达65%,明显高于西沙必利对照治疗组(P＜0.05);危重症患者心排血指数、全身氧输送和氧消耗明显高于生理范围,但胃肠道仍处于严重缺血、低氧状态;大黄对血流动力学和全身氧输送和氧消耗无明显影响,但大黄能显著提高胃肠粘膜内pHi(P＜0.001),说明大黄能明显改善胃肠道氧合和功能状况.结论大黄能改善危重症患者胃肠粘膜的血液灌流和氧合状况,对应激性胃肠粘膜病变和中毒性肠麻痹有较好的疗效.
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