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Use of Ciprofloxacin children With severe infections in pediatric intensive care unit
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-5760.2001.03.008
- Key Word:
- 环丙沙星;感染;儿童
Abstract： 目的评价环丙沙星治疗小儿重症感染的有效性和安全性.方法收集北京儿童医院儿童加强医疗病房(PICU)重症感染患儿26例,环丙沙星用量10～20mg@kg-1@d-1,静脉给药,疗程4～31d(11±7)d.结果用药前培养菌对环丙沙星的敏感率为100%.用药5天后6例培养出7株耐药菌,耐药菌发生率占23.1%(6/26).其中4例环丙沙星治疗无效改换敏感抗生素.继发霉菌感染者4例,占15.4%(4/26),2例死于霉菌败血症.本组患儿治愈11例,好转出院6例,无效9例,总有效率为65.4%(17/26).耐药菌株出现和霉菌感染是治疗失败的主要原因.仅1例患儿治疗过程中出现皮疹,副作用发生率为3.8%(1/26).结论环丙沙星是治疗儿童严重感染的一种相对安全有效的药物.
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