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The tissue distribution of endotoxin in septic rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1003-515X.2000.06.001
- Key Word:
- 内毒素;脓毒症;多器官功能障碍综合征
Abstract： 目的:探讨脓毒症时组织内毒素的分布特征及其与多器官损害的关系.方法:采用盲肠结扎穿孔(CLP)致大鼠脓毒症模型,分别于伤前及伤后2、8、16h测定血浆及组织内毒素含量.结果:CLP后2h血浆内毒素含量急剧增加,约为术前值的17.1倍,其后迅速下降;伤后组织内毒素水平均不同程度上升,其中以肝组织升高幅度最大.肝组织内毒素水平于8h达峰值,肺组织内毒素则持续升高,而肾组织其含量各时相点无显著性差异(P＞0.05).同时,反映肝、肺、肾等脏器功能指标均呈现不同程度的异常改变;相关分析表明,血浆内毒素与肺组织髓过氧化物酶活性显著正相关(P＜0.01).结论:CLP后循环内毒素水平急剧升高,并迅速分布至肝、肺、肾等组织,引起局部组织内毒素积聚;而组织内毒素可刺激机体炎症反应,参与脓毒症的发病过程.
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