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Changes in levels of nitric oxide and activities of nitric oxide synthase in cerebellum after carbon monoxide poisoning in rat
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-5760.2000.03.001
- Key Word:
- 急性一氧化碳中毒;一氧化氮;一氧化氮合酶;小脑
Abstract： 目的:研究急性一氧化碳(CO)中毒大鼠小脑组织中一氧化氮(NO)、一氧化氮合酶(NOS)活性的变化,以探讨NO、NOS与急性CO中毒脑损伤的关系.方法:实验用Wistar大鼠26只,随机分为两组:正常对照组(C组),CO染毒组(CO组).采用改良的Griess法、分光光度法分别测定小脑组织中NO、NOS活性.结果:CO中毒后小脑组织中NO明显增高(P<0.05),NOS活性明显降低(P<0.01).结论:急性CO中毒脑组织损伤与小脑组织中NOS活性受抑制、NO含量增高有关.
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