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Effects of pentoxifylline in dogs with endotoxic shock
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-5760.2000.03.001
- Key Word:
- 休克;脓毒性;己酮可可碱;血液动力学;内脏血流
Abstract： 目的:研究己酮可可碱(PTX)在内毒素休克时所起的作用.方法:选用成年杂种犬12只,随机分成2组,第一组(n＝6)按250μg/kg持续静注内毒素30min,第二组(n＝6)除用同样的方法静注内毒素外,在静注内毒素前按20mg/kg静推PTX后按20mg.kg-1.h-1持续静注PTX.两组动物从开始到结束持续静注生理盐水维持CVP及PCWP在基础水平.每隔半小时测量一次MAP、MPAP、CVP、PCWP、HR、CO、肠系膜上动脉的血流量.并于0'、90'、180'、240'作动脉血、肺动脉血、肠系膜上静脉血血气分析,计算CI,SVI,SVRI,PVRI和DO2,VO2,O2ER等.结果:两组实验动物均产生休克,平均动脉压下降30%以上.与对照组相比,PTX能进一步降低内毒素休克犬的外周血管阻力,并使心脏指数及肠系膜上动脉的血流量增加.增加全身及肠系膜上动脉所供胃肠组织的氧输送(P<0.05).结论:己酮可可碱可显著改善内毒素休克犬的血液动力学及缺血脏器的血供、氧供.对感染性休克治疗有益.
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