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Effects of high frequency ventilation and inhaled nitric oxide in rabbits with meconium aspiration
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1673-4386.2000.03.008
- Key Word:
- 高频通气;常频通气;吸入一氧化氮;胎粪吸入综合征;兔
Abstract： 目的:评价实验性胎粪吸入(MAS)联合应用吸入一氧化氮(iNO)和高频通气(HFV)或常频通气(CMV)的治疗效果.方法:新西兰白兔气管切开插管常频机械通气,气道内滴入胎粪3～4ml/kg约30min后出现MAS模型,表现为肺顺应性(Cdyn)下降>30%,动脉血氧分压(PaO2)<10kPa,随机分为对照组(机械通气)和治疗组(机械通气+iNO),每组中先用CMV 3h后改HFV 3h(CMV-HFV),或先用HFV 3h后改CMV 3h(HFV-CMV).结果:在治疗开始的3h,对照组HFV-CMV和治疗组HFV-CMV以及CMV-HFV的氧合指数(OI)均有显著下降(P<0.05),在继续治疗的3h(6h),对照组CMV-HFV的OI无任何改善,对照组HFV-CMV的OI明显恶化(P>0.05),而治疗组CMV-HFV和HFV-CMV的OI较治疗前均有改善,但无统计学意义.结论:治疗实验性胎粪吸入联合应用iNO和CMV或iNO和HFV对早期氧合的改善较单用CMV更为有效.
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