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Changes of relationship between oxygen delivery and oxygen consumption in rats during hemorrhagic Shock
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1671-0282.2000.02.005
- Key Word:
- 氧消耗;氧供给;失血性休克;大鼠
Abstract： 目的研究失血性休克时全身氧供给(DO2)与氧消耗(VO2)关系的变化.方法按4ml/kg、每隔0.5小时分次从静脉放血,观察大鼠休克过程中DO2、VO2、氧摄取率(ExtO2)等变化.结果失血2.0小时平均动脉压开始明显下降(P＜0.01).在休克早期,DO2随进行性下降,ExtO2出现代偿升高、VO2维持相对不变,呈非氧供依赖关系;当DO2降至27.64ml·min-1·kg-1后、VO2随DO2线性降低(r＝0.788,P＜0.01),即呈氧供依赖关系,并伴血乳酸浓度升高.结论失血性休克时DO2与VO2间呈双相变化关系,氧供依赖关系出现反映了全身组织缺氧的存在.
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