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The changes and significance of endothelin,nitric oxide and platelet alpha-granule membrance protein 140 in acute myocardial ischemia
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2000.01.006
- Key Word:
- 冠心病;内皮素;一氧化氮;血小板α颗粒膜蛋白140
Abstract： 目的:探讨急性心肌梗死(AMI)及不稳定心绞痛(UA)患者周围血中内皮素(ET)、一氧化氮(NO)、血小板α颗粒膜蛋白140(GMP-140)的变化及意义.方法:选择发病12h内入院的AMI患者30例,于入院即刻取血.UA患者30例,于UA疼痛发作时取血.分别测定周围血中ET、NO、GMP-140浓度.正常对照组30例.结果:AMI及UA患者血浆ET、GMP-140浓度均明显高于正常对照组,其变化依次为AMI组＞UA组＞正常组.NO的变化与之相反.AMI组与UA组ET与GMP-140呈正相关(r＝0.602,P＜0.01,r＝0.401,P＜0.05);两组NO与GMP-140负相关(r＝-0.606,P＜0.01,r＝-0.504,0.01＜P＜0.05);未见ET与NO存在相关性(P＞0.05).结论:冠状动脉粥样硬化急性缺血时,ET、NO的平衡失调与活化的血小板相互作用,加速冠状动脉内血栓形成与痉挛,导致急性心肌缺血的发作.
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