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Effect of magnesium sulfate on the permeability of blood-brain barrier after brain injury in rat
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2000.01.004
- Key Word:
- 脑损伤;血脑屏障;硫酸镁
Abstract： 目的:探讨硫酸镁对大鼠颅脑创伤后血脑屏障通透性的影响及可能的机制.方法:在SD大鼠颅脑创伤的同时腹腔注射硫酸镁治疗,伤后24h测定颅脑创伤组及硫酸镁治疗组大鼠挫伤灶边缘脑皮质含水量,用伊文氏蓝作为示踪剂定量观察血脑屏障的通透性,并做超微结构观察.结果:硫酸镁治疗组大鼠脑皮质含水量及伊文氏蓝含量均明显低于颅脑创伤组.超微结构观察也发现硫酸镁治疗组血脑屏障的破坏程度较创伤组减轻.结论:在颇脑创伤早期应用硫酸镁可以有效地减轻血脑屏障破坏的程度.
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