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The dynamic alteration and implication of endothelin and calcitonin gene-related peptide following severe brain trauma
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1671-0282.1999.06.005
- Key Word:
- 内皮素;降钙素基因相关肽;脑损伤
Abstract： 目的:探讨重型颅脑损伤后内皮素(ET)、降钙素基因相关肽(CGRP)的动态变化及其意义.方法:对29例重型颅脑损伤病人(GCS≤8分)在伤后6h内,3d,7d测定血浆ET、CGRP含量,并与36例正常人对照,分析其变化规律及与预后的关系.结果:重型颅脑损伤后6h内ET及CGRP含量即急剧升高,并在一周内始终维持在较高的水平.预后良好者(GOS 3～5组),早期ET含量及E/C比值均明显低于预后不良者(GOS≤2组).而不同预后组间CGRP含量则无明显差异.结论:对重型颅脑损伤患者进行ET、CGRP含量测定有助于早期判断预后.
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