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Changes of apoptosis in rats of acute ischemic renal injury under the treatment of tetrandrine
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1671-0282.1999.06.003
- Key Word:
- 粉防己碱;细胞凋亡;急性缺血性肾损伤;缺血-再灌流
Abstract： 目的:探讨粉防己碱在急性缺血性肾损伤中的作用及与细胞凋亡的关系.方法:在钳夹双侧肾蒂45min致大鼠急性缺血性肾损伤模型的基础上,采用肾组织切片HE染色、肾组织DNA片段分析及原位末端转移酶标记法等技术,定性、定量分析了急性缺血性肾损伤时肾小管上皮细胞的凋亡现象.结果:急性缺血性肾损伤时,肾小管上皮细胞的凋亡现象明显增加;粉防己碱对急性缺血性肾损伤具有保护作用,能够明显降低受损肾小管的细胞凋亡水平.结论:急性缺血性肾损伤时,中药粉防己碱能够调节肾小管上皮细胞的凋亡水平,以减轻肾组织的损伤.
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