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Comparison of hemodynamic and oxygen metabolism effects of dobutamine and dopamine in postcardio-tomy patients with low cardiac output syndrome
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1671-0282.1999.02.003
- Key Word:
- 多巴酚丁胺;多巴胺;血流动力学;氧代谢
Abstract： 目的:比较小剂量多巴胺及多巴酚丁胺对心脏手术后低心排综合征患者血流动力学和氧代谢的影响.方法:12例心脏手术后低心排患者分别持续静脉泵入5～10μg.min-1.kg-1多巴胺或多巴酚丁胺,观察血流动力学和氧代谢的改变.结果:与给药前相比,10μg.min-1.kg-1多巴胺和5～10μg.min-1.kg-1多巴酚丁胺给药后均能显著提高心脏指数(CI),但同样使CI增加50%～70%,多巴酚丁胺只需5μg.min-1.kg-1,而多巴胺需要10μg.min-1.kg-1.5～10μg.min-1.kg-1多巴酚丁胺使体血管阻力指数(SVRI)和肺动脉嵌顿压(PAWP)显著降低,而多巴胺对SVRI和PAWP无显著影响,两者对肺动脉压(PAP)和肺血管阻力指数(PVRI)均无显著影响.5～10μg.min-1.kg-1多巴酚丁胺均导致氧输送指数(DO2)和氧耗指数(VO2)显著提高,但5～10μg.min-1.kg-1多巴胺对DO2和VO2无明显影响.结论:与多巴胺相比,多巴酚丁胺更为有效的提高CI和DO2、降低心脏前后负荷,有助于改善组织缺氧.
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