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Effect of rhubarb on tumor necrosis factor in the development of lung injury after intestinal ischemia-reperfusion in rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1671-0282.1999.02.001
- Key Word:
- 大黄;肺毛细血管通透性;肠缺血;肿瘤坏死因子
Abstract： 目的:利用大鼠小肠缺血再灌流(IIR)模型,评价肿瘤坏死因子(TNF)在IIR所致肺损伤发病过程中的作用;观察大黄对TNF影响,探讨大黄防治肠源性肺损伤的机理.方法:SD大鼠随机分为4组:1)肠缺血再灌流组(n＝24);2)假手术组(n＝16);3)大黄治疗组(n＝24);4)安慰剂组(n＝16).以125I标记小牛血清白蛋白(BSA)肺摄取指数作为评价肺毛细血管通透性的指标,以髓过氧化物酶(MPO)作为评价多聚核白细胞(PMN)在组织中聚集的指标,采用放射免疫分析法,分别测定各组动物不同时间血浆及肺组织TNF含量.结果:大黄可明显抑制再灌流导致的肺MPO活性升高(P＜0.01)及肠缺血期和再灌流早期出现的血浆及肺组织TNF水平升高(P＜0.01);降低肺毛细血管通透性(P＜0.01).结论:早期应用大黄有助于防止大鼠IIR所致肺损伤的发生,这种作用至少部分是通过抑制IIR诱导的TNF释放而实现的.
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