Abstract： Objective To observe the therapeutic effect offluconazole and Yupingfeng dection for the treatment of deep candidiasis in mice.Methods Set up the model of deep candidiasis in mice.Survival time,devour rate and content of NO,TNF-α are observed.Results In non-immunosuppressive condition,the survival time of Fluconazole and unit group was separately (9.10± 1.43) day and (9.20± 1.62)day.They had significant difference comparing with model group(8.00± 1.63)d.The content of NO,TNF and pp of Yupingfeng dection and unit group were (90.00±4.50)μmol/L,(0.52±0.05)nmol/L,(40.20±2.60)％ and (89.90±4.20) μmol/L,(0.45 ±0.05) nmol/L,(40.50±2.50) ％ separately.In immunosuppressive condition the survival time and content of NO TNF,pp of Yupingfeng dection and unit group had significance difference comparing with model group,which were (7.90 ± 1.86) day,(83.90± 4.10) μmol/L,(0.72 ± 0.05) nmol/L,(39.90±2.80) and (8.4± 1.91) day,(83.50 ±4.20) μmol/L,(0.52 ±0.04)nmol/L,(39.20± 1.90)％ separately,they had significant difference comparing with model group(6.40± 1.90)d,(86.60±3.80)μmol/L,(4.22±0.23)nmol/L,(25.30±2.30)％.Conclusion Yupingfeng dection had an effect for the treatment of deep candidiasis in mice particularly for the immunosuppressive mice.The combination of Yupingfeng dection and fluconazole can boost the therapeutic effect and its mechanism may be related to the immunoregulation.