Molecular genetic mechanisms of basal cell carcinoma

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Author:
CHEN Jie(Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China)
CHEN Ming-hua(Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.022
Key Word:
Carcinoma, basal cell; Hedgehog; Signal transduction

Abstract: Basal cell carcinoma (BCC) is the most common skin cancer in human.Recent studies have indicated that mutations in sonic hedgehog (SHH) signaling pathway play an important role in the occurrence of BCC.The key members of SHH pathway include SHH,PTCH1,SMO and GLI.PTCH1 mutations is correlated with the disturbance in SHH signaling pathway.The overexpression of SMO as well as abnormal activities of the transcription factor GLI can upregulate the transcription and expression of genes related to cell proliferation and growth,and finally contribute to the development of BCC.The suppression of small-molecule inhibitors of SHH pathway on tumors may provide new ideas for the treatment of BCC.

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