Molecular mechanisms underlying the induction of vascular endothelial growth factor expression by pituitary tumor transforming gene

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Author:
CAO Hua-li(Department of Dermatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China)
ZHENG Min(Department of Dermatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.017
Key Word:
Neoplasms; Blood vessels; Pituitary neoplasms; Vascular endothelial growth factor

Abstract: Pituitary tumor transforming gene (PTTG) can induce the expression of vascular endothelial growth factor (VEGF),one of the most important angiogenic growth factors for tumor angiogenesis,to promote tumor angiogenesis.It has been revealed that PTTG can transactivate the inhibitor of DNA binding-3 (ID3)and fibroblast growth factor-2 (FGF-2) by interacting with PTTG binding factor (PBF) and specificity protein 1 (Sp1).PTTG can also regulate the transcription of matrix metalloproteinase-2 (MMP-2),thrombospondin-1 (TSP-1) and thioredoxin-1 (Trx-1) through other pathways,which are all involved in the mechanisms underlying the induction of VEGF expression by PTTG.

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