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Molecular mechanisms underlying the induction of vascular endothelial growth factor expression by pituitary tumor transforming gene

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 5

DOI:: 10.3760/cma.j.issn.1673-4173.2012.05.017

Key Word:: 肿瘤;血管;垂体肿瘤;血管内皮生长因子;Neoplasms;Blood vessels;Pituitary neoplasms;Vascular endothelial growth factor

Abstract： Pituitary tumor transforming gene (PTTG) can induce the expression of vascular endothelial growth factor (VEGF),one of the most important angiogenic growth factors for tumor angiogenesis,to promote tumor angiogenesis.It has been revealed that PTTG can transactivate the inhibitor of DNA binding-3 (ID3)and fibroblast growth factor-2 (FGF-2) by interacting with PTTG binding factor (PBF) and specificity protein 1 (Sp1).PTTG can also regulate the transcription of matrix metalloproteinase-2 (MMP-2),thrombospondin-1 (TSP-1) and thioredoxin-1 (Trx-1) through other pathways,which are all involved in the mechanisms underlying the induction of VEGF expression by PTTG.

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