Regulatory T cells and T helper 17 cells in psoriasis

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Author:
L(U) Yun-tong(Department of Dermatology, Military General Hospital of Beijing PLA, Beijing 100125; Anhui Medical University, China)
WANG Wen-ling(Department of Dermatology, Military General Hospital of Beijing PLA, Beijing 100125)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.014
Key Word:
T-lymphocytes; Th17 cells; Psoriasis

Abstract: Psoriasis is an autoimmune disease associated with T lymphocytes.Recent research has shown that besides T helper type 1 cells,regulatory T (Treg) cells,especially the Treg and T helper 17 (Th17) cells whose generation is induced by the forkhead-box/winged-helix transcription factor Foxp3,play an essential role in the pathogenesis of psoriasis.Among them,Foxp3 + Treg cells play a key role in the exacerbation of psoriasis when the balance between immunosuppression and immune activation is shifted.The cytokines produced by Th17 cells,including interleukin (IL)-17A,IL-17F,IL-22,IL-23,IL-36,tumor necrosis factor (TNF)-α,and so on,play important roles in the initiation and progression of dermatoses.Psoriasis is a muhifactorial disease with the collaborative involvement of many immune cells including Treg and Th17 cells,as well as cytokines.

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