Aryl hydrocarbon receptor participates in the development of autoimmune dermatoses: an update on mechanisms

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Author:
WANG Xiao-wen(Department of Dermatology, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, China)
LI Chun-ying(Department of Dermatology, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, China)
GAO Tian-wen(Department of Dermatology, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.011
Key Word:
Autoimmune dermatosis; Receptors, aryl hydrocarbon; Th17 cells

Abstract´╝Ü Aryl hydrocarbon receptor,a cytosolic transcription factor,takes part in many biological processes including immune response,endocrine secretion,melanin synthesis and metabolism of low-molecular-weight molecules.Recent research has confirmed that aryl hydrocarbon receptor can interfere with immune system and result in allergic reaction and autoimmune response via interacting with low-molecular-weight chemicals.Also,aryl hydrocarbon receptor plays an important role in the development of autoimmune dermatoses.The authors review aryl hydrocarbon receptor signaling pathway,immunological functions and its association with autoimmune dermatoses,which may help to understand the pathogenesis of autoimmune dermatoses,and offer new ideas for immunotherapy of diseases.

  • [1]Sun YV,Boverhof DR,Burgoon LD,et al.Comparative analysis of dioxin response elements in human,mouse and rat genomic sequences.Nucleic Acids Res,2004,32 (15):4512-4523.
  • [2]Beischlag TV,Luis Morales J,Hollingshead BD,et al.The aryl hydrocarbon receptor complex and the control of gene expression.Crit Rev Eukaryot Gone Expr,2008,18(3):207-250.
  • [3]Hahn ME,Allan LL,Sherr DH.Regulation of constitutive and inducible AHR signaling:complex interactions involving the AHR repressor.Biochem Pharmacol,2009,77(4):485-497.
  • [4]van Leeuwen FX,Feeley M,Schrenk D,et al.Dioxins:WHO's tolerable daily intake (TDI) revisited.Chemosphere,2000,40(9-11):1095-1101.
  • [5]Kr(a)mer HJ,Podobinska M,Bartsch A,et al.Malassezin,a novel agonist of the aryl hydrocarbon receptor from the yeast Malassezia furfur,induces apoptosis in primary human melanocytes.Chembiochem,2005,6(5):860-865.
  • [6]Veldhoen M,Hirota K,Christensen J,et al.Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells.J Exp Med,2009,206(1):43-49.
  • [7]Hirabayashi Y,Inoue T.Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells.Biochem Pharmacol,2009,77(4):521-535.
  • [8]Jux B,Kadow S,Esser C.Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice.J Immunol,2009,182(11):6709-6717.
  • [9]Veldhoen M,Hirota K,Westendorf AM,et al.The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins.Nature,2008,453(7191):106-109.
  • [10]Matsumura F,Puga A,Tohyama C.Biological functions of the arylhydrocarbon receptor:beyond induction of cytochrome P450s.Introduction to this special issue.Biochem Pharmacol,2009,77(4):473.
  • [11]Hauben E,Gregori S,Draghici E,et al.Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated eflects on regulatory T cells.Blood,2008,112(4):1214-1222.
  • [12]Lawrence BP,Denison MS,Novak H,et al.Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound.Blood,2008,112(4):1158-1165.
  • [13]Negishi T,Kato Y,Ooneda O,et al.Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance.J Immunol,2005,175 (11):7348-7356.
  • [14]Jeon MS,Esser C.The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor,a member of the evolutionarily conserved bHLH-PAS transcription factor family.J Immunol,2000,165(12):6975-6983.
  • [15]Quintana FJ,Basso AS,Iglesias AH,et al.Control of T(reg) and T (H)17 cell differentiation by the aryl hydrocarbon receptor.Nature,2008,453(7191):65-71.
  • [16]Aujla SJ,Chan YR,Zheng M,et al.IL-22 mediates mueosal host defense against Gram-negative bacterial pneumonia.Nat Med,2008,14(3):275-281.
  • [17]Wolk K,Kunz S,Witte E,et al.IL-22 increases the innate immunity of tissues.Immunity,2004,21 (2):241-254.
  • [18]Liang SC,Tan XY,Luxenberg DP,et al.Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.J Exp Med,2006,203(10):2271-2279.
  • [19]Martin R,O'Shea J,Birnbaum LS,et al.Community corner.Striking the balance in multiple sclerosis.Nat Med,2008,14(5):491.
  • [20]D'Cruz D.Autoimmune diseases associated with drugs,chemicals and environmental factors.Toxicol Lett,2000,112-113:421-432.
  • [21]Naldi L,Chatenoud L,Linder D,et al.Cigarette smoking,body mass index,and stressful life events as risk factors for psoriasis:results from an Italian case-control study.J Invest Dermatol,2005,125(1):61-67.
  • [22]Richter-Hintz D,Their R,Steinwachs S,et al.Allelic variants of drug metabolizing enzymes as risk factors in psoriasis.J Invest Dermatol,2003,120(5):765-770.
  • [23]Nguyen LT,Ramanathan M,Weinstock-Guttman B,et al.Detection of cytochrome P450 and other drug-metabolizing enzyme mRNAs in peripheral blood mononuclear cells using DNA arrays.Drug Metab Dispos,2000,28(8):987-993.
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