Immunological mechanisms in chronic idiopathic urticaria

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Author:
SUN Li-wei(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
SHAO Juan(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
CHEN Xian-jin(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
YAN Li-ping(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
KANG Er-xun(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
LI Jie()
YANG Jian()
HAN Chun-yu(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
XIA Xiu-juan(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
ZHOU Su-rong(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
GAO Dong(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
YAO Xian-ping(Department of Dermatology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, Shandong, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.010
Key Word:
Urticaria; Immunity; Autoantibodies

Abstract: The etiology of chronic idiopathic urticaria (CIU) remains unclear.Recent studies have found that autoimmune mechanisms are involved in the development of CIU in most cases.Several autoantibodies have been found to be associated with CIU.In these autoantibodies,the anti-FcεRI and anti-IgE antibodies appear to play key roles in the pathogenesis of CIU.B lymphocyte stimulator may take part in the production of autoantibodies.Moreover,the frequency of HLA-DRB 1*04 allele is higher in patients with CIU,suggesting a genetic background underlying autoimmune CIU.

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