Nrf2 activators counteract oxidative stress: an update

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Author:
DENG Hui-yan(Guangzhou Institute of Dermatology, Guangzhou 510095, China)
ZHU Hui-lan(Guangzhou Institute of Dermatology, Guangzhou 510095, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.009
Key Word:
Nrf2 activator; Antioxidants; EGCG; Curcumin; Sulforaphane

Abstract: Ultraviolet radiation can not only induces acute and chronic inflammation in skin,but also trigger oxidative stress response tollowed by the production of reactive oxygen species (ROS).The Nrf2-Keapl system can counteract ROS via regulating the expression of protective genes in cells.As Nrf2 activators,natural antioxidants,such as (-)-epigallocatechin-3-gallate (EGCG),curcumin and sulforaphane counteract oxidative stress by directly scavenging free radicals or indirectly increasing endogenous cellular antioxidant defenses.In detail,these activators may activate Nrf2 by binding to Nrf2 or Keap1 with different chemical structures followed by alteration of configurations,which in turn initiates anti-oxidative stress response to counteract ultraviolet-induced oxidative stress.

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