Methods to improve transdermal delivery of aminolevulinic acid

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Author:
SHI Lei(Shanghai Skin Disease Hospital, Shanghai 200050, China)
WANG Xiu-li(Shanghai Skin Disease Hospital, Shanghai 200050, China)
WANG Hong-wei(Shanghai Skin Disease Hospital, Shanghai 200050, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.008
Key Word:
Photochemotherapy; Aminolevulinic acid; Transdermal; Delivery vehicles

Abstract: Aminolevulinic acid-based photodynamic therapy (ALA-PDT) has been extensively applied in dermatology.However,the low permeability of ALA across intact skin has limited the efficacy of ALA-PDT.To enhace the percutaneous penetration of ALA,esterified derivatives,microneedles,laser,iontophoresis,delivery vehicles have been used in succession,and some achievements have been made.These methods can increase the transdermal delivery of ALA in terms of depth and quantity by different mechanisms,and indirectly promote the efficacy of ALA-PDT in dermatoses.

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