Efficacy of 5-aminolevulinic acid-based photodynamic therapy and CO2 laser for verruca plantaris

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Author:
LUO Dong(Department of Dermatology and Venereology,People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China)
LIANG Jun-qin(Department of Dermatology and Venereology,People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China)
ZOU Xiao-hui(Department of Dermatology and Venereology,People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China)
PU Xiong-ming(Department of Dermatology and Venereology,People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.004
Key Word:
Verruca plantaris; Aminolevulinic acid; Photochemotherapy; Laser

Abstract: Objective To compare the efficacy of 5-aminolevulinic acid-based photodynamic therapy(ALA-PDT) versus CO2 laser for verruca plantaris.Methods A total of 136 patients with verruca plantaris were recruited in this study,and equally divided into two groups to be treated with ALA-PDT and CO2 laser respectively.Results Significant differences were observed in the cure rate (86.8% (59/68) vs.100% (68/68),P < 0.05) and recurrence rate (13.6% (8/59) vs.29.4% (20/68),P < 0.05) between patients treated with ALA-PDT and those with CO2 laser.Conclusions The cure rate is higher in patients treated with CO2 laser than in those with ALA-PDT,while ALA-PDT seems safer with a lower recurrence rate and less pain.Nevertheless,multiple treatment sessions and considerable cost have limited the clinical application of ALA-PDT.

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