Abstract： Objective To compare the efficacy of 5-aminolevulinic acid-based photodynamic therapy(ALA-PDT) versus CO2 laser for verruca plantaris.Methods A total of 136 patients with verruca plantaris were recruited in this study,and equally divided into two groups to be treated with ALA-PDT and CO2 laser respectively.Results Significant differences were observed in the cure rate (86.8％ (59/68) vs.100％ (68/68),P ＜ 0.05) and recurrence rate (13.6％ (8/59) vs.29.4％ (20/68),P ＜ 0.05) between patients treated with ALA-PDT and those with CO2 laser.Conclusions The cure rate is higher in patients treated with CO2 laser than in those with ALA-PDT,while ALA-PDT seems safer with a lower recurrence rate and less pain.Nevertheless,multiple treatment sessions and considerable cost have limited the clinical application of ALA-PDT.