A case of dermatofibrosarcoma protuberans

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Author:
ZENG Ting(Department of Dermatology and Venereology, Second Xiangya Hospital, Central South University, Changsha 410011, China)
ZHANG Gui-ying(Department of Dermatology and Venereology, Second Xiangya Hospital, Central South University, Changsha 410011, China)
LIAO Zhi-ling(Department of Dermatology and Venereology, Second Xiangya Hospital, Central South University, Changsha 410011, China)
WEN Hai-quan(Department of Dermatology and Venereology, Second Xiangya Hospital, Central South University, Changsha 410011, China)
SU Yu-wen(Department of Dermatology and Venereology, Second Xiangya Hospital, Central South University, Changsha 410011, China)
XIAO Rong(Department of Dermatology and Venereology, Second Xiangya Hospital, Central South University, Changsha 410011, China)
LU Qian-jin(Department of Dermatology and Venereology, Second Xiangya Hospital, Central South University, Changsha 410011, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.05.001
Key Word:
Dermatofibrosarcoma; Case reports

Abstract: A 52-year-old female patient presented with erythematous nodules and plaques for 10 years in the left lower abdomen,which had been aggravated in the past half year.Physical examination revealed several soy bean-to finger-sized,smooth,soft,rubber like,erythematous papules and nodules,and a few irregularly sized,moderately indurated subcutaneous nodules and masses with a yellowish red smooth surface in the left lower abdomen,giving a rough appearance.Skin biopsy revealed a large number of spindle tumor cells arranged in a storiform pattern throughout the full-thickness dermis and subcutaneous tissue with the involvement of skin appendages.A few mitotic figures were observed in some tumor cells.Immunohisto-chemistry of the tumor cells showed positive staining for CD34,vimentin and BCL-2,but negative staining for neuron specific enolase (NSE),synaptophysin (Syn),soluble protein 100 (S-100),smooth muscle actin (SMA) and XⅢa.A diagnosis of dermatofibrosarcoma protuberans was made according to the clinical,histopathologic and immunohistochemical manifestations.The patient received extended radical excision followed by skin grafting and achieved a satisfactory outcome.No recurrence was observed during a 5-month follow up.

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