Granulomatous perioral dermatitis: two case reports

( views:183, downloads:0 )
Author:
WANG Liu-yuan(Guangdong Provincial Centers for Skin Disease and STI Control and Prevention, Guangzhou 510500, China)
WU Tie-qiang(Guangdong Provincial Centers for Skin Disease and STI Control and Prevention, Guangzhou 510500, China)
GU You-shou(Guangdong Provincial Centers for Skin Disease and STI Control and Prevention, Guangzhou 510500, China)
YANG Bin(Guangdong Provincial Centers for Skin Disease and STI Control and Prevention, Guangzhou 510500, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 02, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.02.003
Key Word:
Dermatitis, perioral;Granuloma

Abstract: Two cases of granulomatous perioral dermatitis are reported.A 6-year-old boy presented with erythema and papules on the face for 5 months,which had been exacerbated after application of topical glucocorticoids.The other patient was a 28-year-old woman,who presented with erythema and papules around the mouth and nose for more than 2 months.Small pink indurated papules measuring 1 to 3 mm in diameter were observed in the periorificial region of both patients.Histopathologic examination of the lesions showed granulomatous changes of epithelioid cells around the follicles in dermis.Both cases were diagnosed as granulomatous perioral dermatitis based on the clinical manifestation and histopathological findings.The lesions in patient 1 completely subsided after 2 months of treatment with oral erythromycin 200 mg 4 times daily as well as topical clindamycin 1% gel and tacrolimus 0.03% ointment,but recurred one month later.The other patient experienced a spontaneous regression of lesions,which hinted a trend to spontaneous cure of this entity.

  • [1]贾虹,陈敏,孙兆圣,等.肉芽肿性口周皮炎一例.国际皮肤性病学杂志,2006,32(6):338-339.
  • [2]Zalaudek 1,Di Stefani A,Ferrara G,et al.Childhood granulomatous periorificial dermatitis:a controversial disease.J Dtsch Dermatol Ges,2005,3(4):252-255.
  • [3]Choi YL,Lee KJ,Cho HJ,et al.Case of childhood granulomatous periorificial dermatitis in a Korean boy treated by oral erythromycin.J Dermatol,2006,33(11):806-808.
  • [4]Mφrtz CG,Deleuran MS.A case of childhood granulomatous pefioral dermatitis (CGPD) in a three year old boy from Madagascar.Ugeskr Laeger,2008,170(5):352.
  • [5]Antony FC, Buckley DA, Russell-Jones R. Childhood granulomatous pefiofificial dermatitis in an Asian gid-a variant of sarcoid? Clin Exp Dermatol,2002,27(4):275-276.
  • [6]Smith KW.Perioral dermatitis with histopathologic features of granulomatous rosacea: successful treatment with isotretinoin.Cutis,1990,46(5):413-415.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn