Peripheral blood eosinophil count is parallel with the severity of bullous pemphigoid: a case report

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Author:
CHEN Ming-fei(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
WANG Guang-jin(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
SHAN Xiao-feng(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
ZHANG Di-zhan(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
ZHOU Gui-zhi(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
CHEN Sheng-li(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
LIU Hua-xu(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 38, Issue 01, 2012
DOI:
10.3760/cma.j.issn.1673-4173.2012.01.003
Key Word:
Pemphigoid, bullous;Oxyphil cells;Glucocorticoids

Abstract´╝Ü To report a case of bullous pemphigoid whose severity is parallel with peripheral blood eosinophil count.A 65-year-old man presented with generalized erythema and blisters for 1 month,which had been aggravated for 15 days.Skin examination revealed irregularly sized blisters with grass-yellow fluid developing on normal skin or erythematous patches in the head,neck,face,trunk,limbs and perineum.Nikolsky's sign was negative.Erythematous erosions were observed and some lesions were covered with greybrown crusts.The chest,back and limbs were predominantly affected by these lesions.Histopathological,direct immunofluorescence (DIF) and indirect immunofluorescence (IIF) examination as well as DIF examination of salt-split skin revealed characteristic changes suggestive of bullous pemphigoid.After admission,he was sequentially given 3 sessions of pulse treatment with high dose glucocorticoids.Routine blood test was performed with regular interval during the treatment,and the results of these tests implied that peripheral blood eosinophil count is parallel to the severity of bullous pemphigoid.

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