Expressions of three sex hormone receptors in primary extramammary Paget's disease and their significance

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Author:
XUE Yan-ning(210042南京,中国医学科学院北京协和医学院皮肤病研究所)
ZENG Xue-si(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042, China)
GU Li-xiong()
CHEN Hao(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042, China)
LI A-mei(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042, China)
SHAO Xue-bao(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042, China)
SUN Jian-fang(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 37, Issue 06, 2011
DOI:
10.3760/cma.j.issn.1673-4173.2011.06.003
Key Word:
Paget's disease, extramammary;Receptors, androgen;Gene expression

Abstract: Objective To investigate the expression profiles of three sex hormone receptors including androgen receptor (AR),estrogen receptor (ER) and progesterone receptor (PR) in primary extramammary Paget's disease (EMPD) and their significance.Methods Immunohistochemical methods were used to examine the expressions of androgen receptor,estrogen receptor and progesterone receptor in formalinfixed paraffin-embedded tissue samples from 30 patients with EMPD.Results Androgen receptor was observed in 19 (63.3%) of the 30 tissue specimens,18 (72%) of the 25 specimens from male patients,and 1 out of the 5 specimens from female patients.Neither estrogen receptor nor progesterone receptor was detected in any of these specimens.Conclusions EMPD is hormone-dependent.Androgens and their receptors may participate in the initiation and progression of primary EMPD.

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