Linear and whorled nevoid hypermelanosis: a case report

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Author:
ZHANG Wei(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College ,Nanjing 210042, China)
CHEN Hao(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College ,Nanjing 210042, China)
LIU Pai(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College ,Nanjing 210042, China)
WU Kan(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College ,Nanjing 210042, China)
SUN Jian-fang(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College ,Nanjing 210042, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 37, Issue 06, 2011
DOI:
10.3760/cma.j.issn.1673-4173.2011.06.001
Key Word:
Linear and whorled nevoid hypennelanosis;Hyperpigmention;Lines of Blaschko

Abstract: A case of linear and whorled nevoid hypermelanosis is reported.A 20-year-old male patient developed hyperpigmented macules over the trunk and extremities soon after birth,which progressively increased.The lesions were arranged in streaks or whorles.Mucous membranes,eyes,palms and soles were spared.Dermatological examination revealed generalized,light tan or deep brown,broad-stripe hyperpigmentation along the Blaschko's lines,which were arranged in streaks on the extremities and in whorles or are shape on the trunk.Skin biopsy revealed increased pigmentation of the basal layer without incontinence of pigmentation.He was diagnosed with linear and whorled nevoid hypermelanosis,and received one-session treatment with Q-switched laser (532 nm),but no obvious improvement was observed.The patient was still followed up.This disease should be diferenfiated from other pigmented disorders,such as incontinentia pigmenti and early linear epidermal nevi.

  • [1]Kalter DC,Griffiths WA,Atherton DJ.Linear and whorled nevoid hypermelanosis.J Am Acad Dermatol,1988,19(6):1037-1044.
  • [2]Claudel P,Labbé L,Pedespan JM,et al.Linear and whorled nevoid hypermelanosis:report of two cases.Arch Pediatr,1998,5(10):1098-1102.
  • [3]Mrobaee AA,Alsaif F.Linear and whorled nevoid hypermelanosis associated with developmental delay and generalized convulsions.Int J Dermatol,2004,43(2):145-147.
  • [4]Llamas-Velasco M,Eguren C,Arranz E,et al.Linear and whorled nevoid hypermelanosis and Axenfeld-Rieger anomaly:a novel association.Acta Derm Venereol,2010,90(3):317-318.
  • [5]Lu Y,Zhu WY.Linear and whorled nevoid hypermelanosis complicated with inflammatory linear verrcous epidermal nevus and ichthyosis vulgaris.J Dermatol,2007,34(11):765-768.
  • [6]Mégarhané A,Vabres P,Slaba S,et al.Linear and whorled nevoid hypermelanosis with bilateral giant cerebral aneurysms.Am J Med Genet,2002,112(1):95-98.
  • [7]Erram I,Turk BG,Urkmez A,et al.Linear and whorled nevoid hypermelanosis:dermatoscopic features.J Am Aead Dermatol,2009,60(2):328-331.
  • [8]Yuksek J,Sezer E,ErbiI AH,et al.Linear and whorled nevoid hypermelanosis.Dermatol Online J,2007,13 (3):23.
  • [9]Hong SP,Ahn SY,Lee WS.Linear and whorled nevoid hypermelanosis:unique clinical presentations and their possible association with chromosmal abnormality inv (9).Arch Dermatol,2008,144(3):415-416.
  • [10]韩长元,来为民线状和漩涡状痣样过度黑素沉着病一例.中华皮肤科杂志,2009,42(9):656.
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