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p14ARF and cutaneous malignancies

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 5

DOI:: 10.3760/cma.j.issn.1673-4173.2011.05.021

Key Word:: 肿瘤抑制蛋白质p14ARF;皮肤肿瘤;Tumor suppressor protein p14ARF;Skin neoplasms

Abstract： P14ARF is a newly discovered tumor-suppressor gene that regulates cell cycle through three independent pathways, i.e., p53, Rb and mitogen-activated protein kinase (MAPK). It has been revealed that the expression of p14ARF is downregulated in many malignant tumors including cutaneous malignancies. p14ARF may be inactivated by gene methylation, deletion and mutation, of which, methylation is the most common. At present, scientists are attempting to use p14ARF as a target to treat malignant tumors and have made initial progress.

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