Roles of T-helper 17(Th17) cells in the pathogenesis of systemic lupus erythematosus

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Author:
XU Xia()
ZENG Fan-qin(Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 37, Issue 05, 2011
DOI:
10.3760/cma.j.issn.1673-4173.2011.05.008
Key Word:
Lupus erythematosus, systemic;Th17 cells

Abstract´╝Ü Systemic lupus erythematosus (SLE) is an autoimmune disorder. Abnormal immune responses mediated by T-helper cells and their cytokines play a role in the pathogenesis of SLE. By secreting interleukin (IL)-17 and IL-21, Th17 cells can trigger inflammation and cause target organ damage, participate in the regulation of both T and B cells, and promote the production of autoantibodies. Evidences are accumulated that Th17 cells play an important role in the initiation and progression of SLE. This paper describes Th17 cell biological features and relationship with SLE.

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