Alopecia in systemic lupus erythematosus

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YE Yan-ting(Department of Dermatology and Venereology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China)
ZHANG Xing-qi(Department of Dermatology and Venereology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China)
Journal Title:
International Journal of Dermatology and Venereology
Volume 37, Issue 05, 2011
Key Word:
Lupus erythematosus, systemic;Lupus erythematosus, discoid;Alopecia

Abstract: Alopecia is a common clinical presentation of systemic lupus erythematosus (SLE). There are various types of alopecia in SLE, such as lupus hair, non-scarring patchy alopecia, diffuse telogen effluvium and patchy scarring alopecia in discoid lupus erythematosus (DLE). These types of alopecia differ from each other in clinical and histopathological manifestations. Alopecia in patients with SLE may be correlated to the disease activity. The pathogenesis of alopecia in SLE is not fully understood, and may be associated with the changes in local microenvironment induced by autoimmune inflammation and vasculitis, hair nutrient deficiency and disturbances of hair follicle cycle.

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