Drug-induced Stevens-Johnson syndrome complicated by acute pancreatitis and secondary cytomegalovirus infection: a case report

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Author:
CAI Ze-ming(Department of Dermatology and Venereology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)
TANG Xu-hua(Department of Dermatology and Venereology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)
HAN Jian-de(Department of Dermatology and Venereology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)
ZHANG Xing-qi(Department of Dermatology and Venereology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)
LIAO Qi-man(Department of Dermatology and Venereology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)
Journal Title:
International Journal of Dermatology and Venereology
Issue:
Volume 37, Issue 05, 2011
DOI:
10.3760/ema.j.issn.1673-4173.2011.05.004
Key Word:
Stevens-Johnson syndrome;Pancreatitis, acute necrotizing;Cytomegalovirus infections

Abstract: A case of bezoar antidotal tablet-induced Stevens-Johnson syndrome complicated by acute pancreatitis and secondary cytomegalovirus infection is reported. A 20-year-old female presented with a 4-day history of painful oral, corneal and vulval erosions and ulcer with fever. Cutaneous examination revealed soybean-sized, edematous erythematous patches scattered over the body, some of these lesions were targetshaped with or without central vesicles and purpura. There were generalized hyperemia and erosions covered by white membranous material and yellow purulent secretions. After hospitalized with a diagnosis of StevensJohnson syndrome, she developed acute pancreatitis and upper gastrointestinal tract bleeding. Her condition improved markedly after timely management, but fever appeared subsequently. The results of blood routine test and serological tests for cytomegalovirus were suggestive of cytomegalovirus infection. The patient completely recovered after 2-week treatment with ganciclovir.

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