Abstract： Objective To determine the changes of urine bFGF level in the progression of cutaneous hemangioma,and to provide an objective index for the monitoring of hemangioma occurrence and development.Methods Enzyme-linked immunosorbent assay (ELISA) was used to determine the bFGF level in urine samples from 27 infants and young children with proliferative cutaneous hemangioma before and after treatment with low-dose superficial X-ray,and from 30 normal control infants and young children.Results The urine bFGF level was significantly higher in the patients before treatment than in those 3 months after the treatment and normal controls(t = 3.793,0.206,both P ＜ 0.05),while no significant difference was observed in the urine bFGF level between the treated patients and controls (t = 0.505,P ＞ 0.05).Conclusions Measurement of urine bFGF level by ELISA is a convenient and reliable method ,which may provide an objective index for the monitoring of hemangioma occurrence and development.