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Roles of Dectin-1 in host immune responses against Candida albicans and underlying mechanisms
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1673-4173.2011.03.018
- Key Word:
- 念珠菌,细胞;免疫;树突细胞;外源凝集素类;C型;Candida albicans,cells;Immunity;Dendritic cells;Lectins,C-type
Abstract： Dectin-1, a principal C-type lectin pattern-recognition receptor, exists in various types of cells and tissues. It can specifically recognize β-glucans, which are the major cell wall component of Candida albicans, and then trigger the innate and adaptive immune responses in hosts. Dectin-1 can independently, as well as collaboratively with other pattern recognition receptors, induce above mentioned processes. The intensity of immune responses in hosts is modulated by multiple factors such as the exposure of β-glucans on Candida albicans and the expression level of Dectin-1, and this modulation may provide a new direction for the prevention and therapy of Candida albicans infection.
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