Mechanisms of antipsoriatic effects of phosphodiesterase 4 inhibitors

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HUANG Ying-xue(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China)
LI Xin-yu(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China)
Journal Title:
Volume 37, Issue 03, 2011
Key Word:
Psoriasis;Cytokines;Phosphodiesterase 4

Abstract: The phosphodiesterase (PDE) 4 is a predominant cyclic adenosine monophosphate (cAMP)degrading enzyme which can mediate inflammatory reactions via several routes. With broad anti-inflammatory activities, PDE4 inhibitors perform an antipsoriatic effect via a multifaceted and multitarget mechanism. Concretely, they can downregulate the production of pre-inflammatory cytokines including tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-12 and IL-23 by modulating gene expression, inhibit the activation of dendrite cells and T cells and reduce the synthesis of inflammatory mediators. In addition, they have an anti-angiogenic potential. The efficacy and safety of PDE4 inhibitors have been confirmed in clinical trails. Thus, selective PDE4 inhibitors have excellent potential as new options for the treatment of psoriasis.

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