Microcystic adnexal carcinoma: a case report

( views:150, downloads:0 )
JIANG Yi-qun(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China)
WAN Chuan()
WU Jian-bing(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China)
SUN Jian-fang(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China)
Journal Title:
Volume 37, Issue 03, 2011
Key Word:
Carcinoma, skin appendage;Sweat gland neoplasms;Rare diseases

Abstract: A case of microcystic adnexal carcinoma is reported. The patient was a 43-year-old female, who had presented with a plaque on the left upper lip for more than 2 years. Skin examination revealed a demarcated, skin-colored plaque measuring 2.5 cm in diameter with telangiectasia on the surface of the left upper lip. Skin biopsy showed that the tumor lied in the dermis, infiltrating deeply into the underlying nervous and muscle tissue. There were many ductal structures and a small number of ramified glands with apocrine features in the upper dermis, strands of basophilic epithelial component imbedded in a markedly hyalinized stroma in the mid and lower dermis, as well as small and round keratinous cysts in the lower dermis. Immunohistoehemistry revealed strong positive staining of the epithelial components with cytokeratin. The staining for CEA and epithelial membrane antigen (EMA) was noted in the superficial ducts and glands. S-100 stain showed the infiltration of peripheral nerve with cytokeratin-positive epithelial components. A diagnosis of microcystic adnexal carcinoma was made. The patient underwent an excisional surgery and was followed up.

  • [1]Goldstein DJ,Barr RJ,Santa Cruz DJ.Microcystic adnexal carcinoma:a distinct clinicopathologic entity.Cancer,1982,50(3):566-572.
  • [2]Wetter R,Goldstein GD.Microcystic adnexal carcinoma:a diagnostic and therapeutic challenge.Dermatol Ther,2008,21 (6):452-458.
  • [3]Yu JB,Blitzblau RC,Patel SC,et al.Surveillance,Epidemiology,and End Results (SEER) database analysis of microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) of the skin.Am J Clin Oncol,2010,33(2):125-127.
  • [4]方微,陈东,商建峰,等.微囊肿附属器癌二例.中华病理学杂志,2009,38(1):59-60.
  • [5]Abbate M,Zeitouni NC,Seyler M,et al.Clinical course,risk factors,and treatment of microcystic adnexal carcinoma:a short series report.Dermatol Surg,2003,29(10):1035-1038.
  • [6]Chiller K,Passaro D,Scheuller M,et al.Microcystic adnexal carcinoma:forty-eight cases,their treatment,and their outcome.Arch Dermatol,2000,136(11):1355-1359.
  • [7]Hoang MP,Dresser KA,Kapur P,et al.Microcystic adnexal carcinoma:an immunohistochemical reappraisal.Mod Pathol,2008,21 (2):178-185.
  • [8]Vidal CI,Goldberg M,Burstein DE,et al.p63 Immunohistochem istry is a useful adjunct in distinguishing sclerosing cutaneous tumors.Am J Dermatopathol,2010,32(3):257-261.
  • [9]Yu Y,Finn DT,Rogers GS.Microcystic adnexal carcinoma:a rare,locally aggressive cutaneous tumor.Am J Clin Oncol,2010,33 (2):196-197.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn