Chronic disseminated candidiasis in two patients with acute leukemia

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Author:
TAO Shi-qin(Department of Dermatology, Wuxi No. 2 People's Hospital, Wuxi 214002,Jiangsu, China)
WANG Zhi(Department of Dermatology, Wuxi No. 2 People's Hospital, Wuxi 214002,Jiangsu, China)
ZHAO Xiao-hong(Department of Dermatology, Wuxi No. 2 People's Hospital, Wuxi 214002,Jiangsu, China)
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
Volume 36, Issue 05, 2010
DOI:
10.3760/cma.j.issn.1673-4173.2010.05.002
Key Word:
Candidiasis;Leukemia;Diffusion

Abstract: Two cases of neutropenic leukemia complicated by chronic disseminated candidiasis (CDC)are reported. One patient suffered from cutaneous ulcer on the left thigh with persistent fever; computed tomography scan showed multiple hypodense lesions in the spleen and nodular patchy shadow in the right lung,fungal culture of the dermal ulcer grew Candida tropicalis. Another patient had fever and bellyache, and fungal blood culture grew Candida tropicalis; computed tomography scan showed multiple hypodense lesions in the liver, spleen, kidney and multiple nodules in lungs. A satisfactory outcome was achieved in both patients after treatment with voriconazole and caspofungin. High risk factors of CDC include persistent neutropenia and preventive administration of antibiotics. A synthetic judgment based on clinical manifestations, microbiological examinations, tissue pathology and imaging findings is recommended for the diagnosis of CDC.

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