Advances in the susceptibility testing of Sporothrix schenckii and treatment of sporotrichosis

( views:, downloads: )
CAI Qing(Department of Dermatology,First Hospital,Jilin University,Changchun 130021,China)
LI Shau-shan(Department of Dermatology,First Hospital,Jilin University,Changchun 130021,China)
LIU Wei-da()
Journal Title:
Volume 36, Issue 01, 2010
Key Word:
Sporotrichosis;Sporotrix;Microbial sensitivity tests;Treatment

Abstract: Spomtrichosis is a subcutaneous infection caused by Sporothrix schenckii,a dimorphic fungus.No unified standard is available at present for in vitro susceptibility testing of dimorphie fungi.Ahhoush saturated solution of potassium iodide.itraconazole and terbinafine have been commonly used in the treatment of sporotrichosis for many years,it is still essential to choose appropriate antifungals.In vitro susceptibility test is not only an important means to the estimate of antifungal activity but also a basis for drug selection.

  • [1]Marimon R,Serena C,Gené al.In vitro antifungal susceptibilities of five species of spomthrix.Amimicrob Agents Chemother,2008,52(2):732-734.
  • [2]Galhardo MC,De Oliveira RM.Valle AC,et al.Molecular epidemiology and antifungal susceptibility patterns of Sporothrix schenckii isulates from a cat-transmitted epidemic of sporotrichosis in Riode Janeiro,Brazil.Med Mycol,2008,46(2):141.
  • [3]Meinerz AR,Nascente Pda S,SchuchLF,et al.In vitro susceptibillty of isolates of Sporothrix schenckii to terbinafine and itraconazole.Rev Soc Bras Med Trop,2007,40(1):60-62.
  • [4]Trilles L,Femández-Torres B,Dos Santos Lazéra M,et al.In vitro antifungal susceptibilities of Sporothrix schenckii in two growth phases.Antimicrob Agents Chemother,2005,49(9):3952-3954.
  • [5]McGinnis MR,Nordoff N,Li RK,et al.Sporothrix schenckii sensitivity to voriconazole,itraconazole and amphotericin B.Med Mycol,2001,39(4):369-371.
  • [6]Kohler LM,Monteiro PC,Hahn RC,et al.In vitro susceptibilities of isolates of SpoFothriX schenckii to itraconazote and terbinafine.J Clin Microbiol,2004,42(9):4319-4320.
  • [7]Kohler LM,Hamdan JS,Ferrari TC.Successful treatment of a disseminated Sporothrix schenckii infection and in vitro analysis for antifungal susceptibility testing.Diagn Microbiol Infect Dis,2007,58(1):117-120.
  • [8]Kohler LM,Soares BM,de Assis Santos D,et al.In vitro susceptibility of isolates of Sporothrix schenckii to amphotericin B.itraeonazole,and terbinafine:comparison of yeast and mycelial forms.Can J Microbiol,2006,52(9):843-847.
  • [9]Alvarado-Ramírez E,Tortes-Rodríguez JM.In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods.Amimicrob Agents Chemother,2007,51(7):2420-2423.
  • [10]Nakai T,Uno J,Ikeda F,et al.In vitro antifungal activity of Micafangin (FK463) against dimorphic fungi:comparison of yeast-like and mycelial forms.Antimicrob Agents Chemother,2003,47(4):1376-1381.
  • [11]Ruíz-Cendoya M,Rodriguez MM,Mariné M,et al.In vitro interactions of itraconazole and mieafungin against clinically important filamentous fungi.Int J Antimicrob Agents,2008,32(5):418.
  • [12]Gutierrez-Galhardo MC,Zancopé-Oliveira RM,Monón A,et al.Antifungal susceptibility profile in vitro of Sporothrix schenckii in two growth phases and by two methods:microdilution and E-test.Mycoses,2009[Epub abead of print].
  • [13]Ghosh A,Chakrabarti A,Hemashettar BM,et al.In vitro susceptibillty pattern of Sporothrix schenckii strains isolated from three centers in India.Indian J Med Res,2001,113:214-20.
  • [14]Marimon R,Cano J,Gené J,et al.Sporothrix brasiliensis,S.globosa,and S.mexican.three new Sporothrix species of clinleal interest.J Clin Microbiol.2007.45(10):3198-3206.
  • [15]Kauffman CA,Bustamante B,Chapman SW,et al.Clinieal practice guidelines for the management of sporotrichosis:2007 update by the Infectious Diseases Society of America Clin Infect Dis,2007,45(10):1255-1265.
  • [16]da Rosa AC,Scrofemeker ML,Vettorato R,et al.Epidemiology of sporotrichosis:a study of 304 cases in Brazil.J Am Acad Dermatol,2005,52(3 Pt 1):451-459.
  • [17]Bonifaz A,Fierro L,Saǘl A,et al.Cutaneous sporotrichosis.Inter mittent treatment (pulses) with itraeonazole.Eur J Dermatol,2008,18(1):61-64.
  • [18]Chapman SW,Pappas P,Kauffmarm C,et al.Comparative evaluation of the efficacy and safety of two doses of terbinafme(500 and 1000 mg/day~(-1))in the treatment of cutaneous or lymphocutaneous sporotrichosis.Mycoscs,2004,47(1-2):62-68.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615