Cutaneous infection of the lower limb with Fonsecaea pedrosoi:a case report

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Author:
HU Zhi-min(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
CHEN Chun-mei(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
ZHOU Xiao-yong(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
ZHANG Liang(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
TONG Zhong-sheng(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
CHEN Liu-qing(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
DONG Bi-lin(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
JIANG Ping(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
DUAN Yi-qun(Deportment of Dermatology,Wuhan First Hospital,Hubei Provincial Center for Infectious Disease Clinical Research,Wuhan 430022,China)
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
Volume 36, Issue 01, 2010
DOI:
10.3760/cma.j.issn.1673-4173.2010.01.003
Key Word:
Blastomycosis;Blastomyces

Abstract: A 53-year-old female patient presented with bandlike lesions on the right lower limb for 30 years.Physical examination revealed a chain of nodules and dull erythematous infihrative plaques covered with dirty crusts.Black dots were observed on the surface of some lesions.Direct microscopic examination and histopathology showed brown chlamydospores.The pathogenic strain was identified as Fonsecaea pedrosoi by fungal culture and molecular biology.Drug sensitivity test in vitro showed that the F.pedrosoi strain was sensitive to itraconazole and terbinafine.The patient was managed with oral itraconazole and terbinafine plus surgical excision and local hyperthermia treatment.After 10-month treatment,purulent discharge disappeared and skin lesions diminished with pigmentation in the lesional sites.Oral itraconazole and terbinafine plus sursical excision and local hypeahermia therapy shows satisfactory efficacy in the management of chromoblastomycosis.

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