Placenta preparations in the treatment of vitiligo

( views:, downloads: )
Author:
LI Jin-chao(Department of Dermatology,Affiliated Hangzhou Clinical College,Anhui Medical University,Hangzhou 310009,China)
XU Aie(Department of Dermatology,Affiliated Hangzhou Clinical College,Anhui Medical University,Hangzhou 310009,China)
WEI Xiao-dong(Department of Dermatology,Affiliated Hangzhou Clinical College,Anhui Medical University,Hangzhou 310009,China)
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
Volume 35, Issue 03, 2009
DOI:
10.3760/cma.j.issn.1673-4173.2009.03.009
Key Word:
Vitiligo;Placenta preparations;Therapy

Abstract: Vitiligo is a common depigmentation disorder,and its treatment remains a challenge.Placenta preparations contain proteins/peptides with molecular weight greater than 3000 and sphingolipids,which can induce melanogenesis through p38 MAPK and promote proliferation and difierentiation of melanoblasts.It has been demonstrated that placenta preparations are a safe and effective treatment with few adverse reactions for vitiligo,especially for childhood vitiligo affecting the scalp.

  • [1]Pal P,Roy R,Datta PK,et al.Hydroalcoholic human placental extract:skin pigmenting activity and gross chemical composition.Int J Dermatol,1995,34(1):61-66.
  • [2]许爱娥,尉晓冬,武家才,等.胎盘中提取的黑素生成素有效成分分析及动物实验.中华皮肤科杂志,2003,36(2):97-99.
  • [3]Sarkar C,Singh SK,Mandal SK,et al.Human placental protein/peptides stimulate melanin synthesis by enhancing tyrosiuase gene expression.Mol Cell Biochem,2006,285(1-2):133-142.
  • [4]Pal P,Mallick S,Mandal SK,et al.A human placental extract:in vivo and in vitro assessments of its melanocyte growth and pigment-inducing activities.Int J Dermatol,2002,41(11):760-767.
  • [5]许爱娥,尉晓冬,毕志刚,等.黑素生成素对MC增殖和黑素合成作用的研究.中华皮肤科杂志,1997,30(1):21-23.
  • [6]Mallick S,Singh SK,Sarkar C,et al.Human placental lipid induces melanogenesis by increasing the expression of tyrosinase and its related proteins in vitro.Pigment Cell Res,2005,18(1):25-33.
  • [7]Singh SK,Sarkar C,Mallick S,et al.Human placental lipid induces melanogenesis through p38 MAPK in B16F10 mouse melanoma.Pigment Cell Res,2005,18(2):113-121.
  • [8]Saha B,singh SK,Sarkar C,et al.Transcriptional activation of tyrosinase gene by human placental sphingolipid.Glycoconj J,2006,23(3-4):259-268.
  • [9]Zhao D,Li Y,Wang P,et al.Melagenine modulates proliferation and differentiation of melanoblasts.Int J Mol Med,2008,22(2):193-197.
  • [10]Saha B,Singh SK,Sarkar C,et al.Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB.Pigment Cell Res,2006,19(6):595-605.
  • [11]Peguet-Navarro J,Sponouch M,Popa I,et al.Gangliosides from human melanoma tumors impair dendritic cell differentiation from monocytes and induce their apoptosis.J Immunol,2003,170(7):3488-3494.
  • [12]许爱娥,尉晓冬.黑素牛成素治疗30例白癜风.中华皮肤科杂志,2001,34(6):458.
  • [13]Xu AE,Wei XD.Topical melagenine for repigmentation in twenty-two child patients with vitiligo on the scalp.Chin Med J (Engl),2004,117(2):199-201.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn