Peroxisome proliferator-activated receptor-gamma agonists in the treatment of dermatoses

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LIN Xi-ran(First Affiliated Hospital of Dalian University, Dalian 116011, China)
HUANG Tian()
Journal Title:
Volume 34, Issue 06, 2008
Key Word:
Peroxisome proliferator-activated receptors;Skin diseases;Therapy

Abstract´╝Ü Recent data have shown that peroxisome proliferator-activated receptor (PPAR)-gamma regulates many biological processes in skin, including cell proliferation and differentiation, immune response and inflammatory reactions. Thus, it may serve as a novel target for the treatment of various skin disorders. Clinically, PPARgamma agonists have been used to treat psoriasis, psoriatic arthritis, atopic dermatitis, melanoma, hirsutism, vascular tumors and lipodystrophy. Investigations into PPAR agonists may develop new approaches to the treatment of skin disorders.

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