Application of 308 nm excimer laser in the treatment of vitiligo and factors affecting its efficacy

( views:464, downloads:0 )
TAO Li(Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China)
YE Ying(Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China)
XIANG Lei-hong(Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China)
Journal Title:
Volume 34, Issue 06, 2008
Key Word:
Vitiligo;Excimer laser;Treatment outcome

Abstract´╝Ü Recently, 308 nm excimer laser has become a promising new modality for the treatment of vitiligo. Compared with traditional phototherapy, 308 nm excimer laser is more user-friendly with satisfactory effect, quick onset of action and fewer adverse reactions. It has been used widely by clinicians in the treatment of vitiligo. A synergistic effect has been found between topical tacrolimus and 308 nm excimer laser in the treatment of vitiligo. There are various factors influencing the effects of 308 nm excimer laser, and this review presents these possible factors, including treatment sites, frequency, sessions, skin phototypes and disease duration, etc.

  • [1]Grimes PE.White patches and bruised souls:advances in the pathogenesis and treatment of vitiligo.J Am Acad Dermatol,2004,51(1 Suppl):S5-S7.
  • [2]Westerhof W,Nieuweboer-Krobotova L.Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-A.Arch Dermatol,1997,133 (12):1525-1528.
  • [3]Njoo MD,Spuls PI,Bos JD,et al.Nonsurgieal repigmentation therapies in vitiligo.Meta-analysis of the literature.Arch Dermatol,1998,134(12):1532-1540.
  • [4]Njoo,MD,Westerhof W,Bos JD,et al.The development of guidelines for the treatment of vitiligo.Arch Dermatol,1999,135(12):1514-1521.
  • [5]Spencer J,Nossa,R,Ajmeri J.Treatment of vitiligo with the 308-nm excimer laser:a pilot study.J Am Acad Dermatol,2002,46(5):727-731.
  • [6]Baltas E,Nagy P,Bonis B,et al.Repigmentation of localized vitiligo with the xenon chloride laser.Br J Dermatol,2001,144(6):1266-1267.
  • [7]Esposito M,Soda R,Costanzo A,et al.Treatment of vitiligo with the 308nm excimer laser.Clin Exp Dermatol,2004,29(2):133-137.
  • [8]Hadi S,Spencer J.The use of the 308-nm excimer laser for the treatment of vititigo.Dermatol Surg,2004,30(7):983-986.
  • [9]Hofer A,Hassan AS,Legat FJ,et al.The efficacy of excimer laser (308nm) for vitiligo at different body sites.J Eur Acad Dermatol Venereol,2006,20(5):558-564.
  • [10]Passeron T,Ostovari N,Zakaria W,et al.Topical tacrolimus and the 308nm excimer laser:a synergistic combination for the treatment of vitiligo.Arch Dermatol,2004,140(9):1065-1069.
  • [11]Hong SB,Park HH,Lee MH.Short-term effects of 308-nm xenon-chloride excimer laser and narrow-band ultraviolet B in the treatment of vitiligo:a comparative study.J Korean Med Sci,2005,20(2):273-278.
  • [12]Hofer A,Hassan AS,Legat FJ,et al.Optimal weekly frequency of 308-m excimer laser treatment in vitiligo patients.Br J Dermatol,2005,152(5):981-985.
  • [13]Taneja A,Trehan M,Taylor CR.308-nm excimer laser for the treatment of localized vitiligo,lnt J Dermatol,2003,42 (8):658-662.
  • [14]Choi KH,Park JH,Ro YS.Treatment of vitiligo with 308-nm xenon-chloride excimer laser:therapentic efficacy of different initial doses according to treatment areas.J Dermatol,2004,31 (4):284-292.
  • [15]Ostovari N,Passeron T,Zakaria W,et al.Treatment of vitiligo by 308-nm excimer laser:an evaluation of variables affecting treatment response.Lasers Surg Med,2004,35(2):152-156.
  • [16]Hadi S,Tinio P,AI-Ghaithi K,et al.Treatment of vitiligo using the 308-nm excimer laser.Photomed Laser Surg,2006,24(3):354-357.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615