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Relationship between the family of interferon regulatory factors and systemic lupus erythematosus
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-4173.2008.04.006
- Key Word:
- 红斑狼疮,系统性;干扰素类;干扰素调节因子类;Lupus erythematosus,systemic;Interferons;Interferon regulatory factors
Abstract： The family of interferon (IFN) regulatory factors exert their function in the pathogenesis of systemic lupus erythematosus (SLE) by regulating lymphocyte differentiation, inducing the production of IFN, and controlling the expression of IFN-related genes. Different interferon regulatory factors positively or negatively modulate SLE through same or different mechanisms. So it may benefit the treatment and prevention of SLE by preparation of the antagonists and/or activators of IFN regulatory factors.
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