Relationship between the family of interferon regulatory factors and systemic lupus erythematosus

( views:331, downloads:0 )
Author:
CAI Yan-tao(Department of Dermatology, Nanfang Hospital, Southern Medical University,Guangzhou 510515, China)
PENG Xue-biao(Department of Dermatology, Nanfang Hospital, Southern Medical University,Guangzhou 510515, China)
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
Volume 34, Issue 04, 2008
DOI:
Key Word:
Lupus erythematosus, systemic;Interferons;Interferon regulatory factors

Abstract´╝Ü The family of interferon (IFN) regulatory factors exert their function in the pathogenesis of systemic lupus erythematosus (SLE) by regulating lymphocyte differentiation, inducing the production of IFN, and controlling the expression of IFN-related genes. Different interferon regulatory factors positively or negatively modulate SLE through same or different mechanisms. So it may benefit the treatment and prevention of SLE by preparation of the antagonists and/or activators of IFN regulatory factors.

  • [1]Blanco P,Pellegrin JL,Moreau JF,et al.Pathophysiology of systemic lupus erythematosus.Presse Med,2007,36 (5 Pt 2):825 -834.
  • [2]Demirci FY,Manzi S,Ramsey-Goldman R,et al.Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematusus (SLE).Ann Hum Genet,2007,71(Pt 3):308-311.
  • [3]Zhuang H,Kosboth M,Lee P,et al.Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.Arthritis Rheum,2006,54(5):1573-1579.
  • [4]Choo A,Palladinetti P,Passioura T,et al.The role of IRF1 and IRF2 transcription factors in leukaemogenesis.Curt Gene Ther,2006,6(5):543-550.
  • [5]Elser B,Lohoff M,Kock S,et al.IFN-gamma represses IL-4 expression via IRF-1 and IRF-2.Immunity,2002,17(6):703-712.
  • [6]Huang X,Hua J,Shen N,et al.Dysregulated expression of interleukin-23 and interleukin-12 subunits in systemic lupus erythematosus patients.Mod Rheumatol,2007,17(3):220-223.
  • [7]Hida S,Tadachi M,Saito T,et al.Negative control of basuphil expansion by IRF-2 critical for the regulation of Th1/Th2 balance.Blood,2005,106(6):2011-2017.
  • [8]Goriely S,Molle C,Nguyen M,et al.Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)-and TLR3-induced IL-12p35 gene activation.Blood,2006,107(3):1078-1084.
  • [9]Yasuda k,Richez C,Maciaszek JW,et al.Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.J Immunol,2007,178(11):6876-6885.
  • [10]Ko J,Gendron-Fitzpatrick A,Splitter GA.Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis.J Immunol,2002,168 (5):2433-2440.
  • [11]Rengarajan J,Mowen KA,McBride KD,et al.Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.J Exp Med,2002,195(8):1003-1012.
  • [12]Lohoff M,Mittru cker HW,Bru stle A,et al.Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells.J Exp Med,2004,200(2):247-253.
  • [13]Tominaga N,Ohkusu-Tstikada K,Udono H,et al.Development of Th1 and Th2 immune responses in mice lacking IFN-regulatory factor-4.Int Immunol,2003,15(1):1-10.
  • [14]Fanzo JC,Yang W,Jang SY,et al.Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity.J Clin Invest,2006,116(3):703-714.
  • [15]Barnes BJ,Richards J,Mancl M,et al.Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection.J Biol Chem,2004,279(43):45194-45207.
  • [16]Graham R R,Kozyrev SV,Baechler EC,et al.A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.Nat Genet,2006,38(5):550-555.
  • [17]Tsujimura H,Tamura T,Ozato K.IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritice ceils.J Immunol,2003,170(3):1131-1135.
  • [18]Paulus C,Krauss S,Nevels M.A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling.Proc Natl Aead Sci U S A,2006,103 (10):3840-3845.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn